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Adults—150 to 300 milligrams (mg) every 6 hours. amitriptyline 25 mg For more severe infections, 300 to 450 mg every 6 hours Children weighing 10 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor The dose is usually 8 to 16 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 or 4 equal doses